The Pharmacy Read List: November 3rd Edition

Happy Monday everyone and welcome back to the Pharmacy Read List! The Read List is a biweekly update on pharmaceutical literature. Every two weeks we handpick one of the most relevant and interesting pharmacy-related publications and summarize it for your convenience. At the end of every month, a quiz on that month’s content will be released. Simply take the quiz, and you’ll be automatically entered into a draw for a gift card prize!

Congratulations to the winner of October’s Pharmacy Read List quiz! The winner will be e-mailed to redeem their prize of a $10 Starbucks Gift Card. For those of you who want to win a prize, check back in 2 weeks for our next quiz.

For this week comes an article on an important subject, cholesterol. Enjoy!
Instructions to access: Copy and paste the article title into UBC Summons to read the full article.

Association between statin use and serum cholesterol concentrations is modified by whole-grain consumption: NHANES 2003-2006

Statins are used to lower cardiovascular disease (CVD) risk in part because of their effects on plasma lipid profiles. Dietary whole grains have also been reported to improve plasma lipid profile but little is known about potential interactions between statins and whole grains. Through this cross-sectional study, the authors aimed to assess the interaction between statin use and whole-grain intake in relation to serum lipid concentrations in adults. Data was obtained from 4284 participants aged ≥45 y in the US National Health and Nutrition Examination Survey (NHANES) from 2003-2006. Usual whole-grain intake was estimated from two 24-h diet recalls by using the MyPyramid Equivalents Database. Participants self-reported statin use. Total and HDL-cholesterol concentrations were measured in all adult participants, and the non-HDL-cholesterol concentration and total cholesterol:HDL-cholesterol (TC:HDL-C) ratio were calculated. Statin usage was 24.9% in all participants (n=1065), and 31.0% of participants (n=1327) consumed ≥16 g whole grains/d. After adjustment for demographic and lifestyle factors, the non-HDL-cholesterol concentration was significantly lower in statin users than in nonusers. This difference was greater in participants who consumed ≥16 g whole grains/d (difference=31mg/dL; P<0.001) than in those who consumed <16 g whole grains/d (difference=20mg/dL; P<0.001) (P-interaction=0.03). Significant interactions were also observed between whole-grain intake and statin use in relation to the TC:HDL-C (P-interaction=0.04) and elevated total cholesterol concentration (P-interaction=0.02). In conclusion, this study revealed that statin users who also consumed ≥16 g (i.e. 1-oz eq) whole grains/d possessed healthier lipoprotein profiles than those who consumed less whole grain or who did not use statins. The findings also suggested that combining whole grains, a healthy dietary component, with statin treatment should not antagonize and may improve the efficacy of statins in adults aged ≥45 y.

– Ainge Chang
B.Sc. (Pharm) Candidate 2016

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